In the last fifty years, the pattern of humidity has changed due to natural and anthropogenic reasons in the southwestern part of Bangladesh. The humidity data was recorded at eight regional meteorological stations of the Bangladesh Meteorological Department over the period of 1974 to 2020 and is used for assessments of trends of humidity aspects in the context of seasonal variability and spatial distribution in the southwestern zone of Bangladesh. For this study, the humidity trend was analyzed through Microsoft Excel Software, and the Arc GIS tool was used for spatial distribution analysis. In Khulna, during the dry season maximum mean humidity was78.6% in 2008 and the minimum mean humidity was 63% in 1974. In the wet season, maximum mean humidity reached 87.5% in 1984 and minimum mean humidity was 78.8% in 1976. In Jessore, the maximum mean humidity in the dry season was 78.8% in 1998 and the minimum mean humidity was 65% in 1975. In the wet season, the maximum mean humidity was 84% in 1990 and the minimum mean humidity was 75.1% in 1979. In Mongla during the dry season maximum mean humidity was 78.6% in 2005 and the minimum mean humidity was 69.6% in 1989. In 2005, during the wet season maximum mean humidity was 86.2% and the minimum mean humidity was 82.7% in 2014. In Satkhira during the dry season maximum mean humidity was 79.2% in 1998 and the minimum mean humidity was 58.4% in 1984. In the wet season, the maximum mean humidity was 82.8% in 1997 and the minimum mean humidity was 72.7 % in 1979. In Barishal during the dry season maximum mean humidity was 83.4% in 1986 and the minimum mean humidity was 71.6% in 1978. In the wet season, the maximum mean humidity was 88.4% in 1975 and the minimum mean humidity was 82.4% in 1982. In Bhola during the dry season maximum mean humidity was 83.6% in 1990 and the minimum mean humidity was 74.4% in 1978. In the wet season, the maximum mean humidity was 89.5% in 1991 and the minimum mean humidity was 82.5% in 2017. In Patuakhali during the dry season maximum mean humidity was 85.8% in 2010 and the minimum mean humidity was 65% in 1982. In 1979, during the rainy season maximum mean humidity was 90.2% and the minimum mean humidity was 78.8%. In Khepupara during the dry season maximum mean humidity was 89% in 1987 and the minimum mean humidity was 57% in 1979. In 1987, the rainy season's maximum mean humidity was 88% and the minimum mean humidity was 78.6%. in 1979. In the southwestern zone of Bangladesh, dry season humidity was consistently increasing trend while wet season humidity was decreasing.